![]() įurthermore, various computational approaches have been tried to identify repurposed or novel leads against EBOV. Recently, we have developed a comprehensive repository of experimentally validated repurposed drugs against 23 viruses (including Ebola virus) responsible for causing epidemics/pandemics. However, our group previously implemented the machine learning approaches to develop computational methods to predict the antiviral compounds against various viruses like flaviviruses, Nipah virus and coronaviruses as AVCpred, anti-Flavi and anti-Nipah and anti-corona, respectively. design the Ser/Thr-protein kinase inhibitors by using machine-trained elastic networks. Matta CF explored the role of biophysical and biological properties in the formulation of QSAR models. explained the importance of physicochemical parameters in the quantitative structure–activity relationship (QSAR) analysis. described the importance of molecular descriptors in the process of designing the efficient drugs. Numerous computational studies are reported in the literature to highlight the use of machine learning in drug development against various pathogens. Likewise, anti-Ebola drug Remdesivir was also repurposed to inhibit murine hepatic virus (MHV), Middle East respiratory syndrome (MERS-CoV), severe acute respiratory syndrome (SARS-CoV) and Nipah virus (NiV). Initially, the Favipiravir was used to treat influenza virus, but now has been used against EBOV. The Favipiravir (6-fluoro-3-hydroxy-2-pyrazinecarboxamide) and Remdesivir (GS-5734) are in use as the broad-spectrum antiviral drugs. ![]() It is the first USFDA-approved therapeutics in 2020 against EBOV infection. INMAZEB, also known as REGN-EB3, is a mixture of three monoclonal antibodies, namely atoltivimab, maftivimab and odesivimab. Among them, Favipiravir and Remdesivir are the ‘experimental’ category drugs that inhibit the viral polymerases while the ZMapp is the mixture of the three monoclonal antibodies, which are directed against the surface glycoproteins. Currently, Favipiravir, Remdesivir, ZMapp and INMAZEB are the four most commonly used anti-Ebola agents for the treatment of EBOV infection. As EBOV is an RNA virus, thus the development of effective antivirals against EBOV is a very challenging task. The structural proteins include the nucleoprotein (NP), glycoprotein (GP), soluble glycoprotein (sGP), RNA-dependent RNA polymerase (L) and four virion proteins (VP24, VP30, VP35, VP40). It constitutes eight structural and one nonstructural proteins. As per WHO, the EBOV outbreak is classified under level 3 emergency due to its high mortality and fatality.ĮBOV is a negative-stranded, enveloped, non-segmented and helical single-stranded RNA with 19-kb nucleotides. EBOV cases are mainly found in the region of sub-Saharan Africa and pass-through animals like a bat, other nonhuman primates or any patient infected with EBOV. ![]() ![]() According to the World Health Organization (WHO), the fatality rate of the EBOV outbreak varies from 25 to 90% ( ). EBOV is responsible for thousands of deaths due to its periodic outbreaks since 1976. Graphic abstractĮbola virus (EBOV) is a member of Filoviridae family also known as Zaire ebolavirus, on the basis of the origin country, i.e., Democratic Republic of Congo (formerly Zaire). We anticipate this will serve the scientific community for developing effective inhibitors against the Ebola virus. The ‘anti-Ebola’ web server is freely available at. The highly robust computational models are integrated into the web server. The robustness of the developed models was cross-evaluated using William’s plot. After a randomization approach, the best predictive model showed Pearson's correlation coefficient ranges from 0.83 to 0.98 on training/testing (T 274) dataset. The robust machine learning techniques, namely support vector machine, random forest and artificial neural network, were employed using tenfold cross-validation. Later, the compounds were used to extract the molecular descriptors, which were subjected to regression-based model development. Three hundred and five unique anti-Ebola compounds with their respective IC 50 values were extracted from the ‘DrugRepV’ database. Therefore, we have developed an 'anti-Ebola' web server, through quantitative structure–activity relationship information of available molecules with experimental anti-Ebola activities. For antiviral drug discovery, the computational efforts are considered highly useful. Despite various efforts from researchers worldwide, its mortality and fatality are quite high. Ebola virus is a deadly pathogen responsible for a frequent series of outbreaks since 1976.
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![]() To be given this quest you will have had to complete the Eclipse Tower (where you learn shadow magic), and be at least a rank 15 gardener. His Gardening Spells and Seed Shop in Silent Market are available only after completing the “Putting Down” quest. It’s also a temporary location for Barley, the gardening vendor of Khrysalis. ![]() The Last Wood teleporter puts you in the middle of the small village (see map), where you can find the Khrysalis gear vendors. This is also the area where you will find the Eclipse Tower, in case you want to train the shift shadow spells or shrike. This boss is interesting if you’re a pet collector, because she drops the Tarantula Hawk pet. The Moon Cliffs teleporter is located underneath the Apiary (see map), which is where you fight the Broodmother. You will find that the Tyrian Gorge teleporter transports you to a spot between the Sky Screamer and the Hundred Legger mobs (see map). This teleporter also leads to Fort Rachias, this time closer to the tower where you face Ghost Dog (see map). The Great Beast (the instance that leads to Ruined Alcazar) is located in Crescent Beach. This is the best teleporter if your destination is Crescent Beach, as there is no teleporter straight to this location. ![]() The first one (see map) is located near Crescent Beach (aka the beginning of Khrysalis part 2). There is space for 6 teleporters there but – strangely enough – only 5 of them seem to be functioning.īoth teleporters 1 and 2 lead to Fort Rachias. To reach the first group of teleporters, take a right turn from the Spiral Door and go towards the little pond. Only, where are they? Which one leads where? I know I always get confused when trying to reach a specific location, so maybe you do too!įirst off, there are two places with teleporters in Khrysalis: one in the Bastion and one in the Silent Market. To make that easier, there are the teleporters of course. Khrysalis is a very long world, so there is lots of running. I was FIRED up and sitting at a Maggiano’s drinking white wine out of a plastic cup. Needless to say the up to 14 business days wait for a response wasn’t going to work for me. We know this isn’t fast enough and we’re doing everything we can to speed up the response time. Because of this, it will take up to 14 business days for us to get back to you. For the past few weeks, we’ve been overwhelmed with gratitude by the response to our sale. I share my busted carry-on story with Away and this is what I get back -> ![]() I finally made it to my new gate with enough time to slam a glass of sauvy b and write to Away about my BUSTED Away Bigger Carry-On: Aluminum Edition PROBLEMS. That’s right my friends I was cradling that bag between terminals and doing my best to not lose any of my personal belongings. Now I want you to close your eyes and picture me walking through O’Hare wearing a suede fringe jacket and holding my BUSTED Away Bigger Carry-On: Aluminum Edition like a baby across one of the world’s largest airports. I popped out of my seat in my new suede fringe jacket that I scored in Jackson Hole to find that my new Away Bigger Carry-On: Aluminum Edition had BUSTED open in the overhead bin like an overstuffed burrito! This is where the Away Luggage Review gets good…My personal belongings were popping out of the overhead bin and I started to sweat and immediately regret wearing the suede fringe jacket. The flight from Jackson Hole to Chicago was short and sweet. There are very few direct flights from Jackson Hole to San Francisco, so I had to connect at O’Hare to get home. I extended my time in Jackson Hole (because Jackson Hole is amazing) but it was time to return home to San Francisco. I’ve shared a couple of quick Away luggage reviews on my Instagram stories over the past couple of months, but I finally had the time to give you the proper Away luggage review that you deserve and need.ĪWAY launched their first-ever online sale and I snagged an Away Bigger Carry-On: Aluminum Edition for 50% off! I was oh-so excited because I had a trip to Jackson Hole, Wyoming in the books and I was ready to take my shiny gold suitcase for a spin.įlash forward to October 1, 2020. ![]() ![]() * trigger warning: AWFUL customer service * Stay AWAY from Away Luggage – Away Luggage ReviewĪnd if you are STILL interested in Away luggage -> save $20 on your first suitcase or bag Macintosh and Windows product keys are cross-platform compatible. MS Word for macOS: 2016, 2019, 2021 Office 365 (locally installed desktop version of Office 365 only) MS Word for Windows: 2010, 2013, 2016, 2019, Office 365 (locally installed desktop version of Office 365 only) Windows 10 or later | macOS 10.14 or later Securely sync your entire library including PDF’s, notes, and annotations across all your devices. Say hello to the brand new EndNote Web, available only to EndNote 21 customers for three years from activation date. Move seamlessly between online and the desktop and iPad applications. With EndNote you can access your research anytime, anywhere from the cloud. With EndNote 21 we are expanding CWYW to be compatible with Google Docs, making it easier to write your next paper and to collaborate on documents with colleagues.Įxperience a new exclusive EndNote Web interface CWYW automatically creates in-text citations and reference lists and easily change the format of your in-text citations and reference lists. Our Cite While You Write (CWYW) tool, makes it easy to insert your EndNote references in a Microsoft Word or Apple Pages document. You can add multiple tags to a reference and anyone who you share your library with can view a tag, making tags a great way to quickly and intuitively organize your references. You can add tags to references and customize the color and name of the tags. Tags are customizable labels that let you organize your references however you'd like. With single reference restoration you can also compare and restore previous versions of individual references. In EndNote 21, you can restore your library and library structure with our new data restoration function, ensuring your research is not lost. If the unthinkable happens, EndNote 21 can recover your library from the cloud and get you back where you belong. EndNote 21 key features Protect your work with data restoration function You can enjoy peace of mind with data restoration functions that protect your work and improve your writing workflow with integrated document creation tools for Google Docs. With EndNote 21 you stay organized using features like tags that enhance productivity. The all new EndNote 21 and EndNote Web help you manage and format citations like never before with bold new features. The best reference management tool is getting even better. Volume or Site License information - PDF flyer.The complete library will be recreated - based on the version that was archived. Click on the File option in the menu bar.Sorry, but we cannot ensure safeness of third party websites. External download links have become invalid for an unknown reason. Use any third party compression software like WinZip or WinRaR instead. Download EndNote 20.0.0 for free Mac Productivity Office Tools EndNote Download Download EndNote The program can not be downloaded: the download link is not available. Note: Compress Library will not work for libraries larger than 4 GB and/or 65,535 files. This will create an archive copy of your library in a single file with the extension.Click on the File option on the menu bar and select Compressed Library (.enlx).Back up your EndNote Library Create a back-up Keep these elements together if copying or moving your Library. a folder with the extension.Data (containing various files connected with the library).Your EndNote library consists of two elements: It can cause issues. You can save backups in the cloud or use EndNote Online. Do NOT save to the cloudĭo NOT save an EndNote Library to cloud syncing folders, such as Dropbox, iCloud or GoogleDrive, if you are still actively adding to it. You can organise references into different groups. We recommend only creating one EndNote Library to avoid issues when inserting references when writing. ![]() Similar to Xbox Live Gold, PlayStation Plus was primarily a way for Sony to monetize the online services of its console hardware, including online multiplayer features. PlayStation Plus has grown stale, and its value has diminished, so a revamp was definitely necessary. “The list of Classic PlayStation Games coming to Sony's new tiers of service read like they were chosen by a company that really thinks you hate old games and won't ever bother to play them,” Giant Bomb co-founder Jeff Gerstmann tweeted.The slim selection and confusing tier differences make the effort feel slapdash, unfocused and incomplete, and I'm curious why Sony didn't detail the whole collection all at once. PS2 games are mysteriously absent, save an assortment of remasters released for the PS4. The announcement listed only 29 titles available to stream, and just 28 downloadable games from older hardware generations.The entire pitch for Premium is cloud gaming, with an assortment of PS3 games available via streaming, but the confirmed launch catalog is filled with arbitrary additions and just a single PSP game.Most of the games are at least a year old, and some far older. Across those tiers, two of them - PlayStation Plus Extra and PlayStation Plus Premium - offer the same catalog of free PS4 and PS5 games to download, though Premium will also offer classic games via both downloading and streaming. There will now be three tiers where there used to be just one.The whole thing is a confusing mess, to put it lightly. The company on Monday finally revealed a partial list of bundled games it plans to make available at launch for the higher-priced tiers of PlayStation Plus, costing $15 and $18 a month. That brings us to PlayStation Plus, and how Sony is positioning the revamped subscription service as the launch approaches at the end of the month. As for whether subscriptions represent a promising new distribution model in the game industry, well … Sony’s top PlayStation exec thinks the jury is still out on that one. ![]() For the PlayStation maker, these services will always come second to its bread and butter: selling full price games at retail for as long as it can maintain high prices and healthy margins. Sony has made its stance on subscription gaming loud and clear. PlayStation Plus annual plans are slapdash, but cheap ![]() ![]() It's when things seem worst that you must not quit. I used it in speeches then and nearly forty years later it hangs on the wall of my office and I am still using it to encourage people NOT TO QUIT. This poem helped create in me a don?t quit attitude in my life while in high school. Published in the Detroit Free Press (March 4,1921). So stick to the fight when you're hardest hit. When he might have won had he stuck it out.ĭon't give up though the pace seems slow,Īnd he learned too late when the night slipped down,Īnd you never can tell how close you are. When the funds are low and the debts are high,Īnd you want to smile, but you have to sigh, When things go wrong, as they sometimes will,Īnd the road you're trudging seems all uphill, He says not to give up the fights even when we are hardest hit, and when things get worse one must never give up.Ask for this YDP anthology at your favorite bookstore or order it online today! We can never tell how close we are to success, though it may seem to be very far, it may be very close to us. Here doubts areĬompared to clouds which stop us from thinking clearly. He declares that success is nothing but failure previously experienced, and the silver lining of a dark cloud of doubt. He repeats not to give up though life may pass slowly and we might succeed with another attempt. Many failures do not remain so, but turn into success and a person who had been losing would have won if he had not given up. He says that life is strange with many twists and turns, and many of us learn it sometimes in our lives. He advises to take a break but not to give up. He says not to quit when money is not sufficient and debts are heavy, when we want to be happy but can only sigh, and when worries are pressing us down. Second line is a comparison-our life and its difficulties. The poet asks us not to quit when things go wrong, and the job we have taken up is very difficult or our life is fraught with difficulties. When we are hardest hit and essentially when things get worse we must never quit. He reiterates that we should stick to the fight Lining to a dark cloud and so we might never know how close we are to success, though the horizon seems far and unreachable. He advises man to rest if heĮdgar A.Guest says life is strange withs its ups and downs and we must move ahead even if the pace of life is slow and strained with failuresĮdgar then goes on to say that "Success is failure turned inside out" and that there is always a silver The poet metaphorically describes life as a road which mightīe "all uphill." That's when man is expected to carry on even when there is a lack or want of money and when debts are mounting. The poem begins with the lines, "When things go wrong ,as they sometimes will." Human beings expect things to go rightĪlways and naturally feel frustated and discouraged at the slightest negative twist or turn in their lives. The poem "DON'T QUIT", written by Edgar Albert Guest has tons of encouragement and optimism. ![]() So stick to the fight when you're hardest hit. When he might have captured the victor's cup,Īnd he learned too late when the night slipped down,Īnd you never can tell how close you are, When he might have won had he stuck it out ĭon't give up though the pace seems slow. When the road you're trudging seems all uphill, When things go wrong, as they sometimes will, ![]() Over 40 years in business, Metro Screenworks is the trusted nationwide leader in custom window screens, screen doors, pool screen, patio screen, pet screen, screening for porches, and everything in between. Whether you’re a contractor or embarking on your own personal screening project, Metro Screenworks provides the quality, durability, performance, and value you need. With over 40 years experience, our family-owned-and-operated company can offer you window screens with the highest quality and most value for your money – with fast delivery. This makes our window screens the perfect choice for new and replacement window screen projects in your home. We also offer your choice of window screen frame color, screen mesh fabric, and screen frame hardware. It is incredibly important that we continue to use window screens and sliding screen doors to protect us and our families from diseases and to keep misguided critters such as curious squirrels out of our homes.Our Complete Window Screens are made to your window screen specifications allowing you to get a replacement screen that fits exactly to-size. Though today, we have better medical care that can easily treat many of the diseases carried by six-legged pests, there are still diseases, such as West Nile, carried by mosquitoes that can cause severe long-term damage and even death. Flies, mosquitoes, and other bugs could no longer bite and infect the food of the people who lived inside. Screens first came to be around the time of the Civil War and with their increased use throughout the years, diseases carried by pests became less and less widespread. There’s a reason for our screens and many of our modern users don’t realize how revolutionary our screens are. If you have a pet who takes their toll on your screens, it can be easy to throw up your hands and decide that your screens are never going to be whole and put up with the pests that make it through your ripped window screens and screen doors. With the multiple widths and lengths that Metro Screenworks offer, there is a roll size that is perfect for your needs! Whether you need to rescreen your window screens, screen door, or porch panels, or you have another project, our multiple screen rolls give you the options you need to get the job done Want to rescreen your windows and screen doors instead of investing in brand new replacement window screen or a screen door? Pet screen rolls are a perfect choice. We offer pet screen in traditional window screen mesh colors, as well as other colors! Pet Screen Rolls Use pet screen for making a hammock, pet beds, bags, hats, patio furniture, and more. This screening material is perfect for other projects that require heavy-duty, structured materials. Pet screen, however, isn’t just for pet owners. Pet screen is made from vinyl-coated polyester which means that it is seven times stronger than fiberglass and aluminum screening material pet screen can withstand claws, teeth, and other stresses that pets put on screens, making it perfect for replacement window screens and screen doors. Pet screen is a heavy duty solution that can allow you to say “goodbye” to ripped screens and “hello” to protection against six- and eight-legged pests. Super screen is perfect for screening any outdoor enclosure for long-lasting pest-protection. Super screen is three times stronger than a regular screen and can provide better protection against pets and weather elements such as hail. It can supplement chicken wire structures to keep bugs and other pests out of your catio. Pet screen is seven times stronger than a regular screen and engineered to withstand pet paws, claws, and teeth. Whether you’ve built an outdoor cat enclosure and are looking to upgrade it or are just starting to look at catio design ideas, pet screen and super screen are some of the best building materials to keep your catio looking and functioning at it’s best. ![]() Learn more about catios and be sure to shop Metro Screenworks for all of your catio design needs. No matter the size of your home or your cat’s habits, you can build a catio that fits your budget and your kitty’s needs. It provides a safe place to let your fur baby play and enjoy the sun. The catio or cat patio is the perfect way to spoil your kitty. ![]() We note that at the time of the second survey some states were still living with some COVID-related restrictions. At November-December 2020, 32% never worked from home and 39% sometimes worked from home, while 29% always worked from home.At May-June 2020, 19% never worked from home, 19% sometimes worked from home, and 62% always worked from home.Before COVID, 58% never worked from home and 35% sometimes worked from home, while 7% always worked from home.At November-December 2020, 36% never worked from home and 37% sometimes worked from home, while 27% always worked from home.At May-June 2020, 30% never worked from home, 22% sometimes worked from home, and 47% always worked from home.Before COVID, 59% never worked from home and 34% sometimes worked from home, while 7% always worked from home.5 Gender differences were most apparent at May-June 2020, with differences less marked at the beginning and end of 2020. Note: Based on on information from respondent about changes in their own and their partner's employment.Īs noted above, taking the individual rather than the couple perspective, it was more common for females to have increased or started working from home during the year. The proportion of respondents reporting that they or their partner never worked from home in November-December 2020 (33%) was considerably lower than the 58% before COVID.įigure 2: Percentages working from home in 2020, if employed.In November-December 2020, when restrictions had been eased in most states, almost 30% of respondents indicated that they or their partner were still working from home, and a further 38% were doing some work from home. ![]()
There’s bound to be plenty more interesting generated cave systems from the latest update, but here’s at least one to check into. We’re getting a massive hollow mountain to explore in this latest seed. Now we’re getting more seeds based around caves and hollow mountains. One of the big updates that came to Minecraft recently involved caves. There’s even a pillager outpost that was generated right on top of a villager house. If you head to the coordinates below, you’ll come across a village that’s built between two giant mountains. This seed has a really interesting village generation. Now fans are hopeful this will end up as a real biome. If you head to the underground coordinates below, you’ll find that there is a underground desert. This seed quickly gained attention online when a player uncovered an unusual find. If you have yet to stumble upon one in the wild, check out this seed and head to -149,62,12 to explore this incredible lush cave out. There’s now lush caves where you’ll find moss and glow berries. Perhaps we’ll start seeing new biomes crafted up to make an underground desert a more common find.Ī new update to Minecraft dived more into caves. Some seeds can really spark some unusual finds. There’s even a small coral colony in the middle of this village. By heading to the coordinates, you’ll stumble upon a desert village that’s actually spawned next to a lake. Just head to -274,62,-170 to find the wreck. But this seed has a full shipwreck that can be found marooned on an island. There are quite a few shipwrecks generated. All you have to do is head to the following coordinates, -877,-27,-1814. In particular, you’ll find a zombie and skeleton spawner if you’re looking to farm some drops. However, you will need to travel to these coordinates to get towards the village hub, 193,-422.Ī player randomly came across this world generation that has two spawners next to each other in a stronghold. With this seed, you’re nearby a massive village which you can easily make use of. Here’s a seed that’s gained some attention online. Unfortunately, there’s no islands on this seed. If you head around 194,-220, you’ll find a massive cliffside area leading to a cove. This seed highlighted online showcases an incredible cove world generation. However, if you look off the island, you’ll find in the distance a floating ship just begging to be explored if you’re able to reach it. You’ll need to scavenge for resources and farm for certain goods to ensure your survival. ![]() This seed will drop you on a large island. Survival island fans we have a seed for you to check out. ![]() There is even a village in the middle of the island that could easily be mistaken for a small fishing village. It makes you spawn on a peaceful island with a few shipwrecks, ruins, and monuments. If you don’t feel like fighting against creepers and are looking for a more relaxed experience, check out this seed. There is also a huge cave entrance on the northern edge of the island, if you feel brave enough to explore it. The island also features a village, a ruined portal, several monuments, shipwrecks, and ocean ruins. This seed features a main island with a mansion, overlooked by a snowy mountain. ![]() ![]() It will bring you to the best caves and cliffs you can find, and if you head to 451,-2,410, you will find a huge cave with an underground waterfall. There is also a village near spawn, a floating village a little further, and a large ocean with a monument.įorget about fresh air with this seed. This seed is filled with exposed upper lush caves for you to discover. It features various biomes, several villages, shipwrecks, temples, portals, and caves. If you are looking for a Minecraft seed with a lot to explore, check out this one. It features all biomes, strongholds, caves, craters, villages, fortresses, and even an amethyst geode at 395,-36,229. This seed has almost everything you could hope for. ![]() Jan Feys, (1973) The Philosophy of Evolution in Sri Aurobindo and Teilhard de Chardin, Calcutta: Firma K.Chetany (1978), The Future of Man According to Teilhard de Chardin and Aurobindo Ghose, New Delhi, Oriental Publishers & Distributors Brookman, Teilhard and Aurobindo: A Study in Religious Complementarity, Mayur Publications, 1988 Beatrice Bruteau (1974), Evolution towards Divinity (Theosophical Publishing House, Wheaton, Ill). ![]()
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